• 👋Hello, please SIGN-UP FOR A FREE account and become a member of our community!
    You will then be able to start threads, post comments and send messages to other members. Thanks!
  • 💪IronMag Labs® 30% Off Easter Sale👉www.ironmaglabs.com Coupon code: EASTER30🐰

Bodybuilding SARMs Articles

basskiller

search, read, learn
Registered
Joined
Jul 23, 2012
Messages
2,470
Reaction score
281
Points
83
Location
My personality is who I am, My attitude is who you
Last edited:
Lgd-4033

One of the members of the Selective Androgen Receptor Modulator category, also known as SARM, is LGD-4033[/URL] It is an oral product that is non-steroidal, but it can offer many of the same benefits as some of the anabolic steroids. The use of LGD-4033 medically includes treatment of muscle wasting. This can be due to issues with cancer or muscle loss due to the natural aging process.

The same benefits as testosterone are also offered with LGD-4033. The difference though is that the user doesn’t have to worry about potential side effects. With testosterone, there can be the risk of the body not responding well or even damage to the liver. Even though this product is taken orally, it isn’t toxic to the liver.

This is one of the most common SARMS used due to how powerful it is. Yet it is also gentle on the body when compared to steroids. For the individual that wants the results but not all of the hassles, this could be exactly what they were looking for.


How does it Work?
This SARM works by binding the androgen receptors selectively. The results of anabolic activity in the muscles and bones occur rather than adversely affecting the glands or the prostate which can occur with the use of steroids. LGD-4033 was recently involved in a study involving volunteers called Phase I Multiple Ascending Dose. This was a random, double blind testing phase that involved a placebo. The goal was to establish that the use of LGD-4033 was safe and easy to tolerate with a dose not to exceed 22 mg per day.

When to use LGD-4033
For many bodybuilders and athletes, the use of LGD-4033 occurs for a bulking phase in order to offer lean body mass and to reduce overall body fat. The use of it can also increase overall strength which allows the individual to take on more challenging workout sessions. When used for bulking, an efficient diet that is high in protein is also necessary. Higher calorie intake may be necessary too if the person will be bulking up by 10 pounds or more. The recommended dose is 5 to 10 mg per day, for a period of 8 weeks.

For a cutting cycle, it may be best to use [COLOR=blue]LGD-4033[/COLOR][/B] a...t worrying about their budget.[/FONT][/COLOR]
 
Last edited:
Andarine S4

Andarine S4

Selective Androgen Receptor Modulators are often referred to as SARMS. Andarine S4 is a research chemical that belongs to this category. It binds to the androgen receptor just like ordinary androgens. The difference though is that selective anabolic activity is created by SARMS.
What is it used for?

The benefit of using Andarine S4 over anabolic steroids ortestosterone is that you don’t have to worry about non-skeletal muscle tissues experiencing androgen activity. Andarine S4 is also used for various types of medical ailements. It may be prescribed to treat:

•Bening Prostatic Hypertrophy
•Muscle wasting
•Osteoporosis

This is an oral product and it can help with creating lean body mass. It can also help with increasing the amount of lean muscle mass. Many people use it so that they can maximize their potential and create the body they really want.
How it is used varies based on what results a person is after. Losing Body Fat (cutting) is the process where the use of Andarine S4 is the most effective. The common steroids used for a cutting cycle include Anavar and Winstrol. Such steroids don’t provide large gains for muscle mass. However, they do help with creating a leaner body. SARMS have similar properties to those steroids. However, they can provide similar results without negative side effects including retaining water.
Dosing

The typical dose for cutting is 50 mg for a cycle of 6 to 8 weeks. The cycle should include using the product daily for 5 days and then taking 2 days off for the duration. Tasking the dose every day for the duration of the cycle can result in changes to vision.


How it Works

The benefits of SARMS include potential for bodybuilders as well as benefits for certain medical conditions. SARMS work by binding to the androgen receptor. This results in the anabolic activity. Through the activation and binding, there is more protein synthesized which allows the muscle to be created. The use of Andarine S4 can result in muscle growth that is quite similar to what a person will gain using various forms of anabolic steroids. However, SARMS don’t offer negative side effects such as those on the prostate or other sexual organs.
Benefits over Steriods

There are several benefits of Andarine S4 over the use of various anabolic steroids. They include:

•Less expensive
•No need for a pre-cycle
•No risk of estrogen related side effects
•No water retention
•Overall sense of well being

Studies

Various studies have been conducted with Andarine S4. Taking 3 mg of it per day can help to restore skeletal muscle according to results on lab rats. A study that lasted for 120 days with this SARM and DHT in rats indicates that bone mass and strength at higher levels were identified with the use of Andarine S4 than with DHT.
Studies indicate that the use of this SARM can result in losing fat and creating lean muscle tissue. The goals can also be achieved in less time than if a person were to take steroids. Even though Andarine S4 is taken orally, it doesn’t pose a risk to the liver so that is also another benefit to consider. It also doesn’t create issues with too much estrogen in the body.
Possible Side Effects

There are some possible side effects to be aware of if you decide to use Andarine S4. Changes in vision is the most common. This is typically only going to occur at a high dose. If it occurs, lower the dose. The vision problems can include trouble seeing at night or a yellow tint. Vision changes will go away after the SARM is no longer in the system.
 
Last edited:
Ostarine MK-2866

Ostarine MK-2866

A type of SARM (short for Selective Androgen Receptor Modulator) is called Ostarine MK – 2866. It is typically prescribed for the treatment and prevention of muscle wasting. Such health concerns can be genetic, due to HIV/AIDS, and other ailments. There are also studies in place that indicate this medication may soon be prescribed as part of hormone replacement therapy (HRT).
SARMS create selective anabolic activity within various androgen receptors. There isn’t any androgenic activity though for the non-skeletal muscle tissues though like there will be with the use of anabolic steroids or the use of testosterone. The use of Ostarine MK-2866 can assist with developing more strength as well as lean muscle tissue.
How it Works

The use of SARMS allows more protein to be synthesized so that the muscle tissue can be created. The use of Ostarine MK-2866 is very similar to the results a person would get taking various forms of steroids. However, they can do so without risk to the various sexual organs including the prostate.
When this SARM is used, there are anabolic results for the muscle tissue. It is a fairly new treatment for serious health problems including cancer and AIDS. It is frequently used by bodybuilders and athletes to provide them with more strength and muscle. It is also used to help them during recovery periods from injuries or surgery. Many athletes take a low dose of 15 mg per day to reduce the risk of an injury. Joint improvement can be noticed in about a week.
When it is Used

There are various types of cycles that a person may select to use Ostarine MK – 2866 for. One of them is a bulking cycle where they want to gain lean muscle tissue. This allows them to gain weight that is mainly muscle. They gains can be as much as 7 pounds and they can be seen over a period of 8 weeks, taking a dose of 25 mg per day. The daily dose shouldn’t be more than 40 mg per day. For the best results it should be taken at the same time each day.
For a cycle of losing body fat known as cutting, reducing calories and increasing workout time can create more muscle. Cutting without the use of SARMS can result in losing muscle mass which can be frustrating. This is due to the drop in hormone levels and a reduction of the metabolic rate. With the use of Ostarine MK-2866, the strength or muscle loss won’t have to be a concern at all. For a cutting cycle, a dose of 15 mg to 20 mg per day for a period of 6 to 8 weeks is taken.
The nutritional value that this SARM offers is also very encouraging. The ability to successfully lose the weight but keep the muscle growth taking place is very important. With the use of steroids, it starts to take longer and longer to see results, but that isn’t the case with Ostarine MK – 2866. . It also won’t cause problems for blood pressure.
Advantages over Steroids

There are many advantages of taking Ostarine MK – 2866over steroids. They include:

•Less expensive
•Not going to alter blood pressure
•Results are seen quickly
•Can help prevent issues with joints and bones due to injuries
•No risk of estrogen related side effects
•No risk of water retention
•Offers nutritional value when cutting calories
 
Last edited:
I was wondering if anyone had any articles/information regarding using andarine to prevent aas induced bph like tamoxifen is used to prevent gyno on cycle. Read it can shrink a prostate through binding to the AR on the prostate but wondering if this binding would be the same in muscle tissue or if it specifically favored AR in the prostate.
 
Enobosarm Ostarine MK-2866

Ostarine is a type of SARM (Selective Androgen Receptor Modulator) that was originally prescribed for the treatment and prevention of muscle wasting. Cancer-induced muscle wasting begins early in the course of a patient's malignant disease. Which when given to the patients, lean muscle mass was observed.
Bodybuilding athletes can and should observe the same as well as strength increase.

Cachexia, also known as muscle wasting, is a complex metabolic condition characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting is associated with cancer, sarcopenia, chronic obstructive pulmonary disease, end-stage renal disease, and other chronic conditions and results in significant morbidity and mortality. Enobosarm (Ostarine MK-2866) is a nonsteroidal selective androgen receptor modulator (SARM) that has tissue-selective anabolic effects in muscle and bone, while sparing other androgenic tissue related to hair growth in women and prostate effects in men

Ostarine is one of the most favorable of any SARMS for being the most anabolic. Of course you can not compare it to anabolic steroids. But in one aspect, you also see none of the side effects you would see with steroids. Depending on the quality of diet, it's not unreasonable to see 6 to 10 lbs of quality lean muscle mass through an 8 week cycle using the higher dose.
Ostarine MK-2866 Works by allowing more protein to be synthesized, hence new muscle tissue is formed. Sarms such as Ostarine MK-2866 This makes for a great addition when bulking.

One of the hardest things about cutting bodyfat is when in doing so, you also can lose a bit of muscle mass. Your fighting millions of years of evolution. The body naturally wants to hang onto bodyfat and will sacrifice muscle first when in a calorie deficit state. By using Ostarine MK-2866, you eliminate the chance of losing quality muscle mass.

SARMS do not aromatize
Nonsteroidal SARMs differ from testosterone and steroidal androgens in several respects. Unlike testosterone, which is converted to active metabolites (i.e. estradiol and DHT), nonsteroidal SARMs do not undergo aromatization or 5-α-reduction. Starting to see why Sarms are becoming so popular.

typical doses rage from 3mgs to 25mgs. Since the half life is around 24 hours, there is no need to dose it but once a day.


Some advantages from using Enobosarm Ostarine MK-2866

• quick results
• increases in total lean body mass
• no water retention
• prevents muscle wasting
• No estrogen rebound
• non suppressive in smaller doses, not clear on very large dosages
• No blood pressure issues have been noted
• non methylated

by basskiller

references
http://www.ncbi.nlm.nih.gov/pubmed/23499390
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177038/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2072878/
 
Last edited:
Selective Androgen Receptor Modulators : Every Bodybuilders Wet Dream Come True



The biological actions of androgens are primarily mediated by the androgen receptor. The androgen receptor is expressed in target tissues as the prostate, skeletal muscle, liver, central nervous system, with the highest expression being produced in the prostate and adrenal gland.

Men with rare mutations of the androgen receptor have lower lean mass and higher bodyfat than normal men. The physiological importance of the androgen receptor has been demonstrated as animal studies that administer androgen receptor antagonist (drugs that block the actions of androgens binding to its receptor) during muscle overload have suppressed muscle hypertrophy.
This suggests that the androgen pathway has a significant effect in exercise-induced muscle hypertrophy and emphasizes the importance of the increase in the number of androgen receptors in exercised muscle. Additionally, when scientists administered the androgen antagonist flutamide, to rats undergoing puberty resulted in a suppressed muscle growth.

Researchers have developed the new non-steroidal drug SARMS which would minimize the side effects of testosterone by promoting full anabolic activity in muscle and bone, while minimizing the undesirable side effects on prostate, hair, skin, and without affecting sperm production and sex-drive. So how the hell are they going to accomplish that?

The beauty of SARMS is that they lack estrogenic activity and do not convert to estrogen..Say goodbye to bitch tits! SARMS also do not under 5a-reduction, which means low binding affinity for the prostate and hair follicles.

In addition, SARMS have full anabolic activity in muscle and bone, yet have minimal effect the on prostate. SARMS are highly specific to the androgen receptor as they have a 1000-fold less binding affinity for any other receptor.

Researchers have been searching for years for a highly orally active anabolic agent that has minimal effects on the liver. SARMS are also orally available and so far seem to have minimal effect on the liver.

Sounds like every bodybuilder's wet dream, but these drugs are in clinical trials right now and the animal research is extremely promising.

In this month's journal of Endocrinology, researchers reported that the SARM drug LGD2226 exhibited anabolic activity on muscle and bone with reduced impact on prostate growth in rats. Interestingly, LGD2226 also increased sex-behavior in male rats.

SARMS is an orally available, non- aromatizable androgen which mediates a number of beneficial effects in bone, muscle, and sexual function independent from the conversion of androgens into estrogens27. So where the hell can you get these drugs? Unfortunately, these drugs are still in the experimental phase of animal research but SARMS well may replace testosterone as it has a greater binding capacity to the androgen receptor yet minimal side effects on the prostate.

So maybe you can put some whiskers on and put on a furry suit and disguise yourself as a 280 pound muscle bound rat and get these drugs before everyone else. On second thought, hold off on that because the first things researchers do to rats to eliminate the confounding activity of different testosterone levels in rats is to cut off their balls!! So unless you want to give up bodybuilding and become an opera singer your gonna have to wait a little longer.

justis berg
 
GW-501516

A PPAR modulator allows the body to use more glucose and to create additional muscle tissue. One of the PPARs is GW-501516. It may be referred to as GW1516 or GSK-516 as well. It can help to reduce and even reverse various problems in men who are obese or that have symptoms of pre-diabetes due to problems with their metabolism. The use of GW-501516 may be a viable treatment for reducing obesity and various conditions that are linked to it.


How does it Work?

GW-501516 is a selective agonist with high affinity and it is very potent. Various studies on this PPAR receptor in lab rats indicates that it regulates the various proteins that the body uses for energy. Rats with high fat and low metabolism were given the product and they were able to lose weight and to increase overall energy levels.


When to Use it

The most common use of GW-501516 is to offer improved endurance levels. However, professional athletes can’t use it because it falls under the category of banned substances. This eliminates any athletes having an unfair advantage over others. For someone looking for a way to quickly boost endurance, this product can help to offer fast results. The common dose is 10 mg per day.

Another popular use for GW-501516 is to reduce body fat. The fat starts to come off quickly and it isn’t catabolic. The loss of fat won’t result in the loss of muscle either so that is a great benefit that users like. It is best to use it for body fat loss in addition to S4 and Ostarine, which are SARMS to ensure that the muscle loss is extremely minimal. The recommended dose is 10 mg per day but many people use as much as 20 mg per day to burn as much fat as they can in in the 8 week cycle.


Potential Risks

There is some debate about the side effects and potential risks involved with using GW-501516. Some of the studies on lab rats give the indication that it can cause cancer. In other studies, the conclusion is that there isn’t enough data to validate or dismiss such a claim. The fact that it isn’t toxic for the liver is important to point out. Since this product works fast, it is less expensive than steroids, it continues to be a popular choice.
 
Last edited:
Back
Top