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How to Use Sustanon 250

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How to Use Sustanon 250
by Bill Roberts

Sustanon 250, whether as the trademarked Schering brand or as another product using the same name, is one of the most popular types of anabolic steroids. Unlike most other steroid injectables, Sustanon comprises a mixture of esters. Specifically, each ampule or mL contains testosterone propionate 30 mg, testosterone phenylpropionate 60 mg, testosterone isocaproate 60 mg, and testosterone decanoate 100 mg. This mixture includes short, medium, and long-acting esters.

For a steroid cycle, there are two advantages to combining multiple esters in the same formulation as Sustanon does.

Using multiple esters allows the fairly high total concentration of 250 mg/mL without requiring a large percentage of solubility enhancers in the vehicle. This is because solubilities of different esters of a steroid are nearly independent of each other. So for example if a vehicle (oil plus solubility enhancers) could dissolve 100 mg/mL of either one steroid ester alone or another alone, it could probably dissolve 200 mg/mL total as a combination of both. The greater total concentration adds convenience for the user.

A second effect of the blending is that extended duration of action can be achieved from including a long-acting ester without having the slow onset of action that such esters have when used alone. From the medical standpoint, it’s desirable that a patient experience benefit shortly after treatment. This is also true for steroid cycles. Because Sustanon contains short-acting esters, it can provide quick effect while also providing a fairly long duration of action.

From the bodybuilding perspective, this is helpful where the bodybuilder does not know how to frontload a steroid. But if he does, frontloading a longer acting single ester will accomplish very nearly the same thing. So, a different testosterone ester product such as testosterone enanthate or testosterone cypionate can very readily be used in an anabolic steroid cycle in place of Sustanon.

The multiple esters in Sustanon result in slightly complex pharmacokinetics or change in drug level with time. With a single ester, after so many hours or so many days blood level falls to one-half of what it had been; then by double that time that falls in half again resulting in one-quarter of the previous level; then by triple that time the level falls to one-eighth of what it had been, etc. This time period is called the half-life.

For Sustanon there is no such fixed time period. I estimate that after the last injection levels drop to one-half by the 4 day point; to one-quarter by the 10 day point; to one-eighth by the 16 day point; and to one-sixteenth by the 23 day point. Or if preferring to work with round numbers in terms of percent, as approximate values levels drop to 40% by day 6; to 30% by day 8; to 20% by day 11; and to 10% by day 18.

How then to use this information in a steroid cycle? While there is no exact black-and-white value, a good figure to work with is that when clomiphene or tamoxifen is correctly used, recovery of LH production may begin when levels from injected androgen have fallen to a level commensurate with ongoing 200 mg/week steroid usage. Stronger recovery can occur as levels fall yet further to about half this or less.

So let’s say Sustanon was used at 500 mg/week. In this case the user would need levels to fall by 40% before recovery might plausibly begin. From the above, this would be at approximately 6 days after the last injection.

If we had another athlete who used the rather high dosage of 2000 mg per week, he would need for levels to drop to 10% of what they had been. This would be at about 18 days past the last injection of the steroid cycle.

So much for the matter of the time required between the last injection and the point where recovery could begin. The remaining question regarding Sustanon’s unusual pharmacokinetics is, How to frontload it?

Ordinarily, determining a frontloading value is simple enough, being calculated from the half-life and the dosing schedule. However, Sustanon does not have any one half-life figure, so there is no mathematically perfect answer. However, we can come more than close enough for practical purposes.
The amount used for frontloading — the first day’s injection amount — should be that which will on average be taken in 5 days, plus the usual dosage. This total value may be rounded for convenience as exactness isn’t required.

So for example if taking 750 mg/week as three injections of 250 mg each, the average daily rate is 107 mg/day (750 mg divided by 7 days.) So the five-day amount works to five times this, or 535 mg. Add what will be the usual injection amount which is 250 mg, we have 785 mg. Because this is an inconvenient amount and absolute precision is not required, I’d round this to 750 mg.

After this, subsequent injections for the steroid cycle are all 250 mg.

This procedure will give proper blood levels much more rapidly than is the case when failing to frontload.

As to dosage, there are many ways to look at it, but a fairly simple and useful one is to categorize Sustanon usage at increments of 250 mg/week.

Usage of 250 mg/week usually amounts to nothing other than high-end testosterone replacement therapy. There is no guarantee that this usage will even cause testosterone levels to exceed the normal range. The dosing is high enough to cause the side effect of suppressed LH production, but in most cases is not high enough for any striking anabolic or fat-loss effects. Depending on individual sensitivity, this amount may be high enough to cause the side effects of gynecomastia if an aromatase inhibitor is not used, or may be enough to cause oily skin or acne. In a few instances, anabolic or fat loss benefits may be impressive, as there are individuals who are high responders. But this isn’t the usual outcome for this dosage level.

500 mg/week. In my opinion, this is a reasonable minimum for an actual steroid cycle. I see little point in suppressing the HPTA but probably failing to get much gains out of it, as is the usual outcome for any dosage much less than this. Again, because testosterone aromatizes to estradiol, an aromatase inhibitor may be required to avoid estrogen-related side effects. No one, I think, will fail to see substantially improved gains at this dosage level compared to natural training, but the rate of improvement may be slow. Eight weeks, however, is sufficient even at this amount for a quite significant improvement, unless of course one has trained for enough time at this usage level to have gotten most of what the individual can obtain from it.

750 mg/week. I would rather see this amount used if choosing to do a cycle. If an aromatase inhibitor is used it is unlikely that increased side effects would be a real reason to prefer 500 mg/weeek over this dosage, and results are very substantially superior.

1000 mg/week. I have no problem with this being the dosage for a first steroid cycle but that is in the context of a serious lifter who understands what he is doing. If the steroid use is in fact cycled — that is to say, there are both on and off periods and the on periods are not overly long, and normalization of function is accomplished in the off periods — this is not an overly aggressive dosage by any means. At this dosage, the superiority over natural training is dramatic.

Lastly, there are of course uses such as 2000 mg/week of Sustanon. I don’t see a reason to go to this until one has achieved such a level of development — relative to the individual — that for example 1000 mg/week has done about all that it can do. In that case, if personal goals call for it, a dose such as this can be completely appropriate.

Regardless of dosing level, frequency of injection should be at least twice per week, and more preferably at least 3x/week.
 
What I got is sust 450 any thoughts thinking of running it for my cruise
 
What I got is sust 450 any thoughts thinking of running it for my cruise

i know the article says three injections a week is good, but if you look at the chart on basskillers site everyday injections is the only way to ensure stable blood levels. thats why i dont like test mixes.
 
I've been told 3 times a week is good I don't mind levels fluctuating I just don't like crashing for example 1 injection a wk on cruise by my 6th or 7th day im crashing I'd rather do at least two preferably 3
 
ImageUploadedByTapatalk1350257736.949234.jpg
A buddy of mine at work needed some
Money for his daughters bday so I bought a couple bottles off him
 
IML Gear Cream!
I honestly prefer Test E. More stable blood levels.
 
I'm going to run it for my cruise at least that's the plan as of now
 
These are the kind of posts everyone needs, very informative. Thanks.
 
Good info
 
Using multiple esters allows the fairly high total concentration of 250 mg/mL without requiring a large percentage of solubility enhancers in the vehicle. This is because solubilities of different esters of a steroid are nearly independent of each other. So for example if a vehicle (oil plus solubility enhancers) could dissolve 100 mg/mL of either one steroid ester alone or another alone, it could probably dissolve 200 mg/mL total as a combination of both. The greater total concentration adds convenience for the user.

For Sustanon there is no such fixed time period. I estimate that after the last injection levels drop to one-half by the 4 day point; to one-quarter by the 10 day point; to one-eighth by the 16 day point; and to one-sixteenth by the 23 day point. Or if preferring to work with round numbers in terms of percent, as approximate values levels drop to 40% by day 6; to 30% by day 8; to 20% by day 11; and to 10% by day 18.

How then to use this information in a steroid cycle? While there is no exact black-and-white value, a good figure to work with is that when clomiphene or tamoxifen is correctly used, recovery of LH production may begin when levels from injected androgen have fallen to a level commensurate with ongoing 200 mg/week steroid usage. Stronger recovery can occur as levels fall yet further to about half this or less.

So let’s say Sustanon was used at 500 mg/week. In this case the user would need levels to fall by 40% before recovery might plausibly begin. From the above, this would be at approximately 6 days after the last injection.

If we had another athlete who used the rather high dosage of 2000 mg per week, he would need for levels to drop to 10% of what they had been. This would be at about 18 days past the last injection of the steroid cycle.

So much for the matter of the time required between the last injection and the point where recovery could begin. The remaining question regarding Sustanon’s unusual pharmacokinetics is, How to frontload it?

Ordinarily, determining a frontloading value is simple enough, being calculated from the half-life and the dosing schedule. However, Sustanon does not have any one half-life figure, so there is no mathematically perfect answer. However, we can come more than close enough for practical purposes.
The amount used for frontloading — the first day’s injection amount — should be that which will on average be taken in 5 days, plus the usual dosage. This total value may be rounded for convenience as exactness isn’t required.

So for example if taking 750 mg/week as three injections of 250 mg each, the average daily rate is 107 mg/day (750 mg divided by 7 days.) So the five-day amount works to five times this, or 535 mg. Add what will be the usual injection amount which is 250 mg, we have 785 mg. Because this is an inconvenient amount and absolute precision is not required, I’d round this to 750 mg.

After this, subsequent injections for the steroid cycle are all 250 mg.

Regardless of dosing level, frequency of injection should be at least twice per week, and more preferably at least 3x/week.

Old thread, but I read it. I've never brewed, but I'm not sure putting things into solution is quite the way Mike describes it. If a solution can dissolve two different esters separately up to 100mg/ml and no more, I'm not sure its quite as simple as combining both to make 200mg/ml when it can't be achieved with one ester. Maybe get a brewer on here to comment. I don't think you can pack more in because different esters are being used.

While sustanon does not have a half life as a whole, you cannot assign certain time frames for how the levels diminish categorically. It does not work like that. Your figures are flawed and are based on a given dose and time. If you took 250 mgs twice per week for a total of 500 mgs per week and reached equilibrium, it would take about 9 days to reach its first half life. The half life would gradually increase as the short esters become less prominent and clear.

If you pin as described above, but only for one week, it still takes between 7-8 days to reach the first half life. One injection of 250 mgs takes 6 days to reach its first half life. One injection of 500 takes between 7-8 days to reach its first half life and its second half life 15 days from injection. Your numbers are not right and seem to be based on quasi math. I can do these calculations with multiple half lives being used with any type of pin schedule

Starting your PCT after 6 days of running Sustanon at 500 per week is far from the truth. That is not right at all. It behaves very similarly to enanthate or cypionate. I can do the math on that and compare as well. The levels stored in depot waiting to be metabolized take nearly three weeks to drop to 200 mgs of stored hormone. If you go by relative metabolization, it takes about 9-10 days to get to the point where you are metabolizing the same amount, in a 500 per week Sus schedule, as you do a 200 per week enanthate schedule (That is with both compounds at equilibrium).

2000mgs per week and only 18 days to drop to 10%? No. Much more than that. Try roughly 40 days.

Your front loading advice is poor. Three injections per week for 750 total by triple dosing only the first pin leaves a lot of ground to still catch up. Triple for the first injection and double dose for the next two injections. Normal 250 after that. For 500 per week, 2.5 for the first injection and double the second injection. The rest are 250. There are a couple different ways to calculate out a front load, but as there is no set half life, you cannot provide a one size fits all front loading method for Sustanon as it will differ depending on weekly dose.

A dose of three times per week is fine when you hit 1000 per week, but it is the same for enanthate and cypionate. These compounds, at equilibrium (because that is what matters on cycle), metabolize at incredibly similar rates. They are all very comparable to each other. This article was a good attempt at solidifying the belief that Sustanon should be treated differently than enanthate or cypionate when the math proves otherwise. The sad part is that all the new guys and "old school" veterans with a 1000 years of cycling under their belts, who can't be told anything and too lazy to do the footwork to learn, will believe this.
 
Best I ever looked and felt was running 750mg sust a week. Pinned 2x a week.

12.5 aromisan ED.

need to to that again.
 
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